Abstract:
Introduction
Obstructive sleep apnea syndrome (SOAS) is characterized
by upper airway obstructions that occur repeatedly during
sleep and cause breathing to stop for more than 10
seconds. Purpose
Research of histopathological changes in patients with
SOAS depending on the degree of severity.
Material and methods
The study was performed in 20 patients diagnosed with
SOAS of different severity, operated in the ENT clinic,
where the fragments of the incised uvula were examined
histopathologically. Contol data on the histopathology of
the normotrophic uvula was taked from literature
(G.Berger, 2002; E.P.Hamans et al., 2000). Results
The results of the histopathological
examination depending on the
severity of SOAS showed on :
mild form - the integrated stratified
squamous epithelium of the uvula was
noted by the presence of small
outbreaks of parakeratosis. The own
lamella and the submucosal
lamina had a total thickness of 1.44 ±
0.03 mm;
moderate form - the total thickness
was 1,603 ± 0.07 mm, which was
significantly higher than in the case of
patients with mild form;
severe form - the total thickness of
the own blade of the mucous and
submucosal layer was 1,635 ± 0.064
mm. Conclusions
The research showed that in patients with SOAS, there are morphological changes in the uvula. The main the "displacement" of the
muscular layer at the base of the uvula. Congestion, the surface of the epithelium of the mucous glands and chronic inflammation
influence the severity of SOAS.
Description:
State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare
