Abstract:
Introduction:
Peritonitis is an inflammatory process
involving cells, a synthesis of proinflammatory
mediators (IL-6, TNF-a) and
anti-inflammatory (IL-10, IL-27), which
maintain inflammation. The cellular-molecular
mechanisms that determine the evolution and
prognosis of peritonitis are not fully
elucidated. Purpose:
Study of the evolutions of cellulo-molecular
changes at the level of peritoneum and blood,
in correlation with the pathogen. Identification
of new methods of diagnosis and treatment in
peritoneal sepsis.
Material and Methods:
The current references from the international
scientific literature were examined, implicitly
the databases of the electronic libraries
PubMed, GeneCards and Annals of
Translational Medicine.
Results:
Peritonitis is an inflammatory process that goes through 2
antagonistic stages - hyperinflammation and
hypoinflammation (immunoparalysis) fig. 1, and as in any
inflammation it goes through several cycles. At each stage
some specific interleukins are secreted, depending on this the
condition of the organism, the prognosis and the adequate
treatment can be diagnosed.The cytokine storm triggered in
peritonitis is interdependent with the pathogen, in table no. 1
with specific biomarkers, for some infections.So far it is not a
specific biomarker to indicate the severity of inflammation and
its prognosis, but a precursor of adrenomodulin has been
found, it is the most sensitive according to the severity of
sepsis, which is a help for ICU, table no.2.
Description:
State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare
