Stem cell niche: location, structure and function

Abstract

Introduction: Stem cell niche is a specific histological structure capable of regulation tissue proliferation and proper functioning. The stem cell niche typically has a spatial organization that provides anatomical and functional interactions. These interactions are mutual and dynamic. Purpose: To study the location, structure and function of the stem cell niche by analyzing bibliographic sources. Material and methods: To realize the research, we reviewed materials from Medscape and PubMed, 2006-2020 yy. We specified the localization of the niche, the types of stem cells and the possible. Results: The niche is basic unit of tissue physiology., integrates signals of proliferation, regeneration, differentiation and migration of stem cells. The niche is formed by the ensemble of stromal cells and factors they produce, including adhesive signals, soluble factors and matrix proteins. Conclusions: Stem cell niche is the microenviroment that maintains stem cell homeostasis.