Pancreatic manifestations of the syndrome MODS / MSO

Abstract

Introduction: Acute necrotizing pancreatitis generates MODS / MSOF syndrome repeatedly, at first onset and then on necrosis infection. Purpose: Elucidation of pancreatic manifestations in severe systemic diseases accompanied by MODS / MSOF syndromeElucidation of pancreatic manifestations in severe systemic diseases accompanied by MODS / MSOF syndrome. Material and methods: Clinic-morphological study included 198 cases of death over a period of 5 years (2015 - 2020). Age over 50 years predominates - 170 cases (85.6%); men - 103 (52%), women 95 (48%) cases. The duration of hospitalization in the ATI department varied: 1 day - 25%, more than 10 days - 18%. Results:Primary diseases: liver cirrhosis, myocardial infarction, BPCO, chronic heart disease were more than half cases. The MODS / MSOF syndrome occurred: cardiorespiratory failure 167 cases (84.3%), liver failure (90 cases (45.4%), acute renal failure 100 cases (50.5%), acute brain failure 39 cases (19.7%). Detected pancreatic morphological manifestations: parenchymal and adipose necrosis, diffuse, extensive and focal - 49 cases (24.7%); pancreatic and peripancreatic necrosis on the background of pancreatic fibrosis - 119 cases. (60.1%); pancreatic autolysis accompanied by outbreaks of necrosis -32 case. (16.2%). Conclusions:MODS / MSOF syndrome burdened with severe systemic disorders generates secondary pancreatic necrosis. The pancreatic response that occurs is usually without obvious clinical manifestations, it must be anticipated in the initiated complex treatment.