Assessment of the domestic pharmaceutical market of combined preparations

Abstract

Introduction. The combined drugs contain in a single preparation two or more agents with different therapeutic action, in a fixed dose. These drugs are involved in several mechanisms which arise in triggering of the pathological condition and increase the likelihood of obtaining amplified therapeutic response. Purpose: Evaluation of the domestic pharmaceutical market of fixed doses combinations of drugs.Material and methods. Analysis of the State Nomenclature of medicines regarding the products authorized in the Republic of Moldova on 30.04.2020. Results In the last 3 years, the number of drugs registered in the RM is decreased of 1.82%. About 10% of the total number is combined products (616 out of 6133). According to the ATC classification, most combinations are in the group “Nervous system” (18%) and “Respiratory system” (17%), and the fewest are in the class “Systemic hormonal preparations” (2%). Of the total number of combined drugs, the remedies used in ear diseases hold a very small percentage, about 0.16%, half of which are analgesic, anesthetic and anti-inflammatory remedies, the rest being antiinfective drugs. Out of the total number of otological drugs, only 7 are combined. Conclusions There is a low number of combined drugs registered in the RM compared to neighboring states, being opportune the researches for the development of new domestic combined products.