Abstract:
Introduction: Migraine is the third most prevalent disease in the world and affects
12% of the general population. It has recently been suggested that
central neurochemical imbalance and low 5-HT levels facilitate the
activation of the trigeminovascular nociceptive pathway, which
therefore initiates migraine.
Purpose: The aim of the study was to describe pathogenetic mechanisms of
migraine according to the newest theories and scientific discoveries.
Material and methods: It was performed a systematic review on scientific papers
concerning the role of serotonin, CGRP and cortical spreading
depression in migraine development. After searching the PubMed,
Hinari and Cochrane Library databases, a total of 247 papers were
screened for relevance, but only 36 papers were selected for further
analysis.
Results: It has been observed an increase in the amplitude of neuronal evoked
potentials following the activation of inhibitory prejunctional 5-HT1B/1D
autoreceptors and 5-HT decreased synthesis. The cortical spreading
depression stimulated the trigeminovascular fibers and determined the
release of CGRP, vasodilation and increased plasma protein extravasation.
Conclusions: Migraine depends on: a) activation of the trigeminovascular system with
increased nociception, and b) dysfunction of CNS structures involved in the
modulation of neuronal excitability and pain.
Description:
State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare