The diuretic activity of Solidago species

Abstract

Introduction. Species of genus Solidago have been known for centuries in European phytotherapy as components of urological remedies with diuretic activity. The therapeutic indications are irrigation of the urinary tract, especially in cases of inflammation and renal gravel and as an adjuvant in the treatment of bacterial infections of the urinary tract. The objective of the study. Bibliographic evaluation of the diuretic activity of g. Solidago species in terms of chemical compounds, mechanisms of action, phytopreparations, etc. Material and methods. Solidago species known as sources of biologically active compounds with diuretic activity are: S. virgaurea, S. canadensis and S. gigantea. Many studies mention flavonoids and saponosides – compounds responsible for the diuretic activity. Acylated triterpenoid saponins transiently change the cell membrane permeability and induce alterations in ionic homeostasis. Recent research attributes this activity to flavonoids and phenolic compounds, especially to the phenolic heteroside – leiocarpozide. Results. Solidago species known as sources of biologically active compounds with diuretic activity are: S. virgaurea, S. canadensis and S. gigantea. Many studies mention flavonoids and saponosides – compounds responsible for the diuretic activity. Acylated triterpenoid saponins transiently change the cell membrane permeability and induce alterations in ionic homeostasis. Recent research attributes this activity to flavonoids and phenolic compounds, especially to the phenolic heteroside – leiocarpozide. On the European pharmaceutical market there are several phytopreparations with diuretic activity, containing extracts of Solidago plant species: Cystinol (Germany), Diuronis (Poland), Urinal Akut (Romania), Uronefron (Moldova). Conclusions. Many studies reflect the importance of Solidago species as valuable raw materials of biologically active natural compounds with diuretic activity.