The predictive variabiles for the structural epilepsy after the hypoxic-ischemic perinatal suffering

Abstract

Introduction. The epilepsy (EP) is one of the leading features in children who have had hypoxic-ischemic perinatal brain lesions (PCL). It can often be associated with mental retardation and often begins at an early age. Purpose. The aim of the study is to determine predictive variables in children who have had PBL depending on the severity of the disease, to assess the risk of developing EP. Material and methods. Prospective study over a period of 2 years, on a group of 614 children, who had moderate (50.5%) and severe (49.5%) PBL. EP was diagnosed in 259 (42.2%) cases, the onset between 3 months and 2 years of age (peak 3-6 months), in children with moderate (27%) and severe (57.6%) PCL. We assessed some determinant variables for EP in the child after PCL based on a study protocol. Results. According to a logistic regression calculation, we determined the following variables with major risk in the development of EP in the child after PBL: (1) intrauterine hypoxia (p <0.001) (2) severe degree of PCL at birth (p <0.006), (3 ) disorders of consciousness (p <0.003), (4) the presence of neonatal convulsions (p <0.004), (5) the pathological electroencephalographic pathway in the first two weeks after birth (p <0.000). The probability of developing EP in the child who underwent PCL in the case of the combination of the 5 variables is high (RP + = 99.7%). Conclusions. The EP can develop at any age, especially in the child with severe PBL, the most vulnerable being the infant age. The association of predictive variables in different numbers and compositions connects various individualized results.