The importance of inflammatory biomarkers in non-valvular atrial fibrilation on anticoagulant treatment

Abstract

Introduction: Atrial fibrillation is independently associated with up to a two-fold higher risk of death. Recently studies highlight that inflammation plays a key role in the initiation, keeping and recurrence of atrial fibrillation. Purpose: To study the importance of inflammatory biomarkers, such as C-reactive protein (CRP) and neutrophil-lymphocyte ratio (RNL), for the risk of severe complications in patients with non-valvular atrial fibrillation. Material and methods: Blood samples were collected in both groups in EDTA and gel-separator tubes, immediately centrifuged. PCR - levels were determined with high-sensitivity immunoassays on the ARCHITECT i8000SR (Abbott Diagnostics) and NLR - levels determined on the CELL-DYN Ruby Hematology System by Abbott Diagnostics. Conclusions: We can mention the importance of RNL and CRP values in identifying patients at increased risk of complications in non-valvular atrial fibrillation, by simple and inexpensive methods in laboratory diagnosis.