Abstract:
Introduction. In hypertension are deregulated
intracellular homeostasis and trans-membranes
transport of magnesium (Mg2+). Magnesium decreases
not only in hypertension, but also in antihypertensive
treatment, especially with diuretics and beta-blockers.
Pharmacologically MgSO4 is a specific antihypertensive
agent, musculotropic vasodilator with direct action on
arteries and veins and it is a unique Calcium (Ca2+)
antagonist, because Mg2+ is a physiological Ca2+
competitor.
Purpose. The importance and efficacy of magnesium
sulfate administration in Hypertensive Encephalopathy
to the Prehospital stage.
Material and methods. Retrospective analysis of the
Prehospital Emergency Medical Service Request
Sheets in Republic of Moldova from 2017 for
Hypertensive and Cardiovascular Emergencies, and for
the treatment of Hypertensive Crises with MgSO4 in
association with standard antihypertensive treatment.
Results. In Republic of Moldova, in 2017, at the prehospital
stage, intravenous administration of MgSO4 in a dose from 1,0
to 5,0 g was effective in the cases of patients with nonresponsive
hypertensive crises on standard antihypertensive
therapy, including hypertensive encephalopathy.
Conclusions. MgSO4 can be an effective drug in the treatment
of Hypertensive Encephalopathy and Crises, if there are no
contraindications, an intravenous dose of MgSO4 of 1,0 (1,25) –
2,5 – 5,0 g, slow, over 5 – 10 – 15 minutes, in association with
standard antihypertensive treatment, is recommended.
Description:
PMSI National Centre of Prehospital Emergency Medicine, Chisinau, Republic of Moldova,
„NicolaeTestemitanu” State University of Medicine and Pharmacy, Department of Medical Emergencies, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare