Abstract:
Abstract
Abstract. The research of this work was to study the morphometric parameters of interlobular arteries in rats
with experimental liver cirrhosis. Liver cirrhosis in Wistar rats was induced with thioacetamide at a dose of 200
mg / kg of animal weight twice a week for 17 weeks. The studied rats were randomized into 9 groups of 12 animals
each. The diameter of the lumen and the thickness of the media of the interlobular arteries in μm were measured
on histological preparations using ImageScope Color, cellSens Standard image analysis software and an OLYMPUS
BX51 microscope. The Kernogan index was calculated. The results were processed using Statistica 10.0 software
from StatSoft, IBM SPSS Statistics 23.0, Microsoft Office Excel.
Based on the data obtained, it was found that in liver cirrhosis, changes in the lumen and thickness of the media
of interlobular arteries do not have a definite pattern. Perhaps this is due to the compensatory-adaptive reactions
of the organ and/or to the fact that the interlobular arteries of the rat liver during fibrogenesis are quite stable.
An increase in the Kernogan index of interlobular arteries indicates a deterioration in vascular capacity at certain
stages of the experiment (stages of fibrosis/cirrhosis), which must be taken into account when conducting preclinical studies.
Description:
Кафедра гистологии, цитологии и эмбриологии, Витебский государственный медицинский университет, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 75 de ani de la fondarea Universităţii de Stat de Medicină și Farmacie Nicolae Testemiţanu, Chişinău, 30-31 octombrie 2020
