Морфометрические показатели междольковых артерий крыс при экспериментальном циррозе печени

Abstract

Abstract Abstract. The research of this work was to study the morphometric parameters of interlobular arteries in rats with experimental liver cirrhosis. Liver cirrhosis in Wistar rats was induced with thioacetamide at a dose of 200 mg / kg of animal weight twice a week for 17 weeks. The studied rats were randomized into 9 groups of 12 animals each. The diameter of the lumen and the thickness of the media of the interlobular arteries in μm were measured on histological preparations using ImageScope Color, cellSens Standard image analysis software and an OLYMPUS BX51 microscope. The Kernogan index was calculated. The results were processed using Statistica 10.0 software from StatSoft, IBM SPSS Statistics 23.0, Microsoft Office Excel. Based on the data obtained, it was found that in liver cirrhosis, changes in the lumen and thickness of the media of interlobular arteries do not have a definite pattern. Perhaps this is due to the compensatory-adaptive reactions of the organ and/or to the fact that the interlobular arteries of the rat liver during fibrogenesis are quite stable. An increase in the Kernogan index of interlobular arteries indicates a deterioration in vascular capacity at certain stages of the experiment (stages of fibrosis/cirrhosis), which must be taken into account when conducting preclinical studies.