Abstract:
Abstract
Background: Angiogenesis is essential for tumor growth and metastasis formation. It is assumed that cancers, after
an early vasculogenic phase, acquire ability to induce new vessels formation. Such phenomenon is referred to as angiogenic
switch. Angiogenic switch depends on the ability to release specific growth factors stimulating blood vessels formation.
The source of those factors is both neoplastic cells and various stromal and immune cells, like mast cells. Mast cells (MCs)
produce a lot of pro-angiogenic and tissue-remodeling factors. Recent works showed that angiogenic factors are already
expressed by the benign lesions. The aim of our study was to investigate the density of CD34-positive blood vessels and
number of tryptase-positive mast cells, as well as to establish correlations between microvessel density and mast cells involved in tumor angiogenesis in prostatic benign lesions.
Material and methods: Our study included 7 cases of normal prostate, 25 cases of benign prostatic hyperplasia. MCs
and the blood vessels were assessed using double immunostaining CD34/MCT.
Results: We have shown a total correlation between that two markers in peritumoral areas (p = 0.001, p <0.01 are
considered significant) and absence of significant correlation between CD34 and tryptase in intratumoral areas.
Conclusions: Our data, as well as, preferential perivascular localization of mast cells and their potential to secrete
vascular endothelial growth factor suggests the involvement of mast cells in pathological angiogenesis process from the
stage of benign prostate proliferative lesions.
Description:
Catedra de histologie, citologie și embriologie, Universitatea de Stata de Medicină și Farmacie „Nicolae Testemiţanu”, Chișinău, Republica Moldova, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015
