Abstract:
Abstract
Background: Hypothyroidism is a common disease. Deficiency of thyroid hormones in the body leads to disruption
of all types of metabolism, causing morphological changes in organs of the musculoskeletal system, so their study would
be a theoretical basis for understanding the pathogenesis of diseases of the musculoskeletal system in hypothyroidism.
Material and methods: During the study of morphofunctional state of the masticatory muscles and temporomandibular joint 20 white outbred male rats were used. Hypothyroidism in animals was caused by introduction of medicine
“Merkazolil” (“Zdorovya”, Ukraine) with drinking water. Structural transformations were studied under an electron microscope.
Results: It was established that during the 14th day of experimental hypothyroidism there were edematous changes
in the haemocapillarry walls, connective tissue elements of capsule and in the articular surface of the temporomandibular
joint, and also striated muscle fibers of masticatory muscles, and their endo- and perimysium.
During the 21st day of hypothyroidism development degenerative changes in the wall of blood vessels, connective
tissue elements of capsule and in the articular surface of temporomandibular joint, and also in muscle fibers in striated
masticatory muscles, and their endo- and perimysium were revealed.
Conclusions: The results of this work can be used to optimize treatment methods and prevention of myopathy and
arthropathy in hypothyroidism.
Description:
Кафедра анатомии человека, оперативной хирургии и топографической анатомии, Ивано-Франковский национальный медицинский университет, Ивано-Франковск, Украина, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015
