Функциональная характеристика височно-нижнечелюстного сустава и жевательных мышц в разные сроки развития гипотиреоза

Abstract

Abstract Background: Hypothyroidism is a common disease. Deficiency of thyroid hormones in the body leads to disruption of all types of metabolism, causing morphological changes in organs of the musculoskeletal system, so their study would be a theoretical basis for understanding the pathogenesis of diseases of the musculoskeletal system in hypothyroidism. Material and methods: During the study of morphofunctional state of the masticatory muscles and temporomandibular joint 20 white outbred male rats were used. Hypothyroidism in animals was caused by introduction of medicine “Merkazolil” (“Zdorovya”, Ukraine) with drinking water. Structural transformations were studied under an electron microscope. Results: It was established that during the 14th day of experimental hypothyroidism there were edematous changes in the haemocapillarry walls, connective tissue elements of capsule and in the articular surface of the temporomandibular joint, and also striated muscle fibers of masticatory muscles, and their endo- and perimysium. During the 21st day of hypothyroidism development degenerative changes in the wall of blood vessels, connective tissue elements of capsule and in the articular surface of temporomandibular joint, and also in muscle fibers in striated masticatory muscles, and their endo- and perimysium were revealed. Conclusions: The results of this work can be used to optimize treatment methods and prevention of myopathy and arthropathy in hypothyroidism.