Морфологические особенности нейронов сенсомоторной коры в условиях малых радиационных воздействий

Abstract

Abstract Background: In experiment investigated the response of neurons of the sensorimotor cortex to ionizing radiation in small doses. The high sensitivity of neurons to the studied factor, but changes in most cases do not go beyond the biological norm, they are reversible, but provides a background for the development of pathological processes (mental and neurological disorders). Material and methods: White male rats irradiated on the γ-rays 60Co single dose of 0,5 Sv with a dose rate of 0,5 Gy/h. Material by months after irradiation. The material taken away at different times post-radiation period. Counted the number of neurons with different tinctorial properties, was calculated the nerve cell index. The obtained data were statistically processed, followed by mathematical modeling. Results: Irradiation causes a more pronounced reaction layer III neurons of the cortex. Increasing the number of neurons with degenerative changes revealed by the end of the observation period. Indicators of nerve cell death index indicate parts of the nerve cells, which affects the number of neurons. Analysis of variance confirmed the absence of marked morphological differences between control and exposed animals. Conclusions: The high sensitivity of neurons to ionizing radiation, but the changes do not go beyond the biological norm. Revealed periods of activation alterative processes and relative prosperity, is a manifestation of cellular adaptation. Changes are reversible after exposure, but create the background for the development of pathological processes. Mental and neurological disorders are detected after irradiation neuromorphological correlates.