Abstract:
Abstract
Background: There are the data indicating the positive influence of itraconazole (I) at fungal infections, non-small
cell pulmonary carcinoma and prostatic cancer. The information about changes in the pulmonary parenchyma under
introduction of I is still scanty. Previously we have noted that parenteral introduction of xenogenic cerebrospinal fluid
(XCSF) results in decrease of intensity of collagen fibers and positive influence over characteristics of lung’s morphometry.
Material and methods: The research was performed on 30 Wistar rats, which were divided into the following groups:
the placebo group, the group which was getting I and placebo, the group which was getting I and XCSF. The animals were
divided into subgroups by sex. The parenchyma was studied by morphological methods.
Results: The introduction of I to Wistar rats resulted in increase of percentage of emphysematous areas at the expense
of decrease of percentage of the areas with intact parenchyma; this effect was more pronounced at female rats. The introduction of XCSF to the female rats, which were getting I, resulted in increase of percentage of the intact areas at the expense
of reduced percentage of emphysematous areas. The introduction of XCSF to male rats, which were getting I, resulted in
increase of emphysematous areas at the expense of reduce of the percentage of non-changed parenchyma; this was also
accompanied by more pronounced collagen formation.
Conclusions: Introduction XCSF female rats has a protective effect, and males - worsened histologic.
Description:
Кафедра нормальной анатомии, Крымский федеральный университет им. В. И. Вернадского, Медицинская академия имени С. И. Георгиевского, Симферополь, Россия, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015