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Половые особенности морфологических изменений паренхимы лёгких крыс при введении итраконазола и коррекции ксеногенной цереброспинальной жидкостью

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dc.contributor.author Шатов, Д. В.
dc.contributor.author Пикалюк, В. С.
dc.contributor.author Киселёв, В. В.
dc.date.accessioned 2020-12-09T20:07:54Z
dc.date.available 2020-12-09T20:07:54Z
dc.date.issued 2015-10
dc.identifier.isbn 978-9975-57-194-4
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/13846
dc.description Кафедра нормальной анатомии, Крымский федеральный университет им. В. И. Вернадского, Медицинская академия имени С. И. Георгиевского, Симферополь, Россия, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015 en_US
dc.description.abstract Abstract Background: There are the data indicating the positive influence of itraconazole (I) at fungal infections, non-small cell pulmonary carcinoma and prostatic cancer. The information about changes in the pulmonary parenchyma under introduction of I is still scanty. Previously we have noted that parenteral introduction of xenogenic cerebrospinal fluid (XCSF) results in decrease of intensity of collagen fibers and positive influence over characteristics of lung’s morphometry. Material and methods: The research was performed on 30 Wistar rats, which were divided into the following groups: the placebo group, the group which was getting I and placebo, the group which was getting I and XCSF. The animals were divided into subgroups by sex. The parenchyma was studied by morphological methods. Results: The introduction of I to Wistar rats resulted in increase of percentage of emphysematous areas at the expense of decrease of percentage of the areas with intact parenchyma; this effect was more pronounced at female rats. The introduction of XCSF to the female rats, which were getting I, resulted in increase of percentage of the intact areas at the expense of reduced percentage of emphysematous areas. The introduction of XCSF to male rats, which were getting I, resulted in increase of emphysematous areas at the expense of reduce of the percentage of non-changed parenchyma; this was also accompanied by more pronounced collagen formation. Conclusions: Introduction XCSF female rats has a protective effect, and males - worsened histologic. en_US
dc.language.iso ru en_US
dc.publisher Probleme actuale ale morfologiei: Materialele Conferinţei ştiinţifice internaţionale en_US
dc.subject itraconazole en_US
dc.subject cerebrospinal fluid en_US
dc.subject parenchyma of lungs en_US
dc.subject correction en_US
dc.subject morphometry en_US
dc.title Половые особенности морфологических изменений паренхимы лёгких крыс при введении итраконазола и коррекции ксеногенной цереброспинальной жидкостью en_US
dc.title.alternative Sexual features of morphological changes in the parenchyma of rat’s lungs under introduction of itraconazole and correction of xenogenic cerebrospinal fluid en_US
dc.type Article en_US


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  • PROBLEME ACTUALE ALE MORFOLOGIEI 2015
    Materialele Conferinţei Ştiinţifice Internaţionale ”Probleme actuale ale morfologiei” dedicate celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015

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