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Dietary improvement of the iron statute of the rats with experimental anemia

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dc.contributor.author Sturza, Rodica
dc.contributor.author Gudumac, Valentin
dc.contributor.author Deseatnicova, Olga
dc.contributor.author Ghendov-Mosanu, Aliona
dc.date.accessioned 2021-01-07T14:18:56Z
dc.date.available 2021-01-07T14:18:56Z
dc.date.issued 2021
dc.identifier.issn 2587-3458
dc.identifier.issn 2587-3466
dc.identifier.uri DOI: 10.38045/ohrm.2021.1.02
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/14820
dc.identifier.uri https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/89/49
dc.description.abstract Introduction. One of the major problems characterizing the nutritional status is the iron deficiency, which leads to decreased immunity, increased incidence of infectious diseases and anemia. Obviously, only well-thought-out corrections can solve these disorders. Material and methods. In order to know the influence of the method of manufacture for iron-fortified products on the iron level, a series of in vivo research was carried out, on a batch of 21 white rats, Wistar line, which were induced experimental drug anemia (EDA). The blood analysis was performed in three stages: initially, after the induction of EDA and after the completion of the experiment. Results. Investigations showed out that during sufficient iron intake rehabilitation of the body iron reserve depends considerably on the presence of antinutritive factors. In order to decrease the influence of these factors, the production method used for fortified products with mineral origin micronutrients (iron) could be based on the use of the lactic-acid fermentation procedures using wheat bran. Conclusions. The research carried out on laboratory animals with induced experimental anemia showed that, in the case of the group fed with bread manufactured by the acid lactic fermentation method, the concentration of serum, iron was completely restored during the experiment, and in the rats fed with fortified bread prepared by the traditional method, the serum iron concentration was only partially restored, 40-45%. en_US
dc.description.abstract Introducere.Una dintre problemele majore care afectează statutul nutrițional este insu-ficiența de fier, care duce la scăderea imunității, la sporirea incidenței maladiilor infecţi-oase şi a anemiilor. Și, evident, numai corecţiile echilibrate pot remedia aceste dereglări. Material si metode. În scopul de a elucida influenţa metodei de fabricare a produselor fortificate cu fier asupra aportuluiacestuia în organism, au fost efectuate o serie de cer-cetări in vivo, pe un lot de 21 şobolani albi, linia Wistar, cărorali s-a indus anemie experi-mentală pe cale medicamentoasă (AEM). Analiza sângelui a fost efectuată în trei reprize: iniţial, după inducerea AEM şi, apoi după finalizarea experimentului.Rezultate.Investigațiile au arătat, că chiar și la un aport suficient de fier, reabilitarea rezervei de fier a organismului depinde considerabil de prezența factorilor antinutritivi. Pentru a reduce influența acestor factori, metoda de fabricație aplicată, pentru produsele fortificate cu micronutrienți de origine minerală (fier), s-ar putea baza pe utilizarea pro-cedurilor de fermentare acido-lactică, folosind tărâțe de grâu. Concluzii. Cercetările efectuate pe animalede laborator, cu anemie experimentală indusă, au demonstrat, că în cazul grupei hranite cu pâine fabricată prin metoda cu fermentaţie acido-lactică, concentraţia fierului seric s-a restabilit complet pe durata experimentului, iar la şobolanii alimentați cu pâine fortificată, preparată prin metoda tradiţională, con-centraţia fierului seric s-a restabilit doar parţial, în proporţie de 40-45%. ro
dc.language.iso en en_US
dc.publisher Asociația de Biosiguranță și Biosecuritate din Republica Moldova en_US
dc.relation.ispartof One Health & Risk Management
dc.subject iron anemia en_US
dc.subject rats en_US
dc.subject in vivo research en_US
dc.subject fortified bread en_US
dc.subject lactic acid fermentation en_US
dc.subject peripheral blood parameters en_US
dc.subject serum iron en_US
dc.subject.ddc UDC: 616.155.194.8-092.9+613.2 en_US
dc.title Dietary improvement of the iron statute of the rats with experimental anemia en_US
dc.title.alternative Ameliorarea dietară a statutului de fier la șobolani cu anemie experimentală en_US
dc.type Article en_US


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