Abstract:
Abstract
Background: Trauma remains a medical-social problem, still having high lethality rate. Indirect lung injury (ILI) occurs in trauma due to systemic
neutrophils activation and proteases release into primarily intact tissues. There are no data in the literature regarding ILI predictive models in trauma.
Material and methods: In the experimental study (19 traumatized male rabbits), the proteases, antiproteases and the pulmonary morphological changes,
assessed according to the SAMCRS score (Semiquantitative Reflected Qualitative Changes Assessment Scale) were followed. There were used two statistical
instruments – correlational analysis and multivariate linear regression.
Results: Initially, a correlational analysis between the values of the SAMCRS score and the proteases/ anti proteases was performed. The null hypothesis
was rejected (F = 7.017, p = .002). The correlation coefficient of the predicted results and the real values of SAMCRSlungs was .854, the determination
coefficient being .626. The final model included the following parameters: constant (B = 9.427; 95% CI 7.341, 11.513; p <.001); α2-macroglobulin0
(B = -4.053; 95% Cl -6.350, -1.757; p = .002); AEAMP0
(B = .002; 95% CI .000, .004; p = .075); AEAMP24 (B = -. 006; 95% CI -.010, -.002; p = .003); AECG2
(B = .081; 95% CI .040, .122; p = .001); AEE0
(B = -. 026; 95% CI -.040, -.011; p = .002).
Conclusions: In this research, a predictive model for indirect lung injury in experimental trauma was developed, the predictors being some elements
of the proteases/antiproteases system. This, in turn, allows the hypotheses emission regarding the pathophysiology, prophylaxis and treatment of ILI.
Description:
Department of Human Physiology and Biophysics, Valeriu Ghereg Department of Anesthesiology and Intensive Care, Nicolae Anestiadi Department of Surgery, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova