Abstract:
Background: Urinary tract infections are the most common urogenital diseases, with an increased incidence in men and older people. Urogenital infections
are caused by Gram-negative bacteria, in which Escherichia coli predominates with a share of 80%. The evolution of microbial resistance to preparations used
in curative-prophylactic institutions, induces the need of the reintroduction of nitrofurans, noteworthy for their wide spectrum of antibacterial activity.
Material and methods: For the study, suppositories with furazidine were prepared by hand rolling and by melting and molding methods. Quantitative
analysis was performed spectrophotometrically on a UV-VIS Perkin Elmer Lambda 40 spectrophotometer. All solvents and reagents had the degree of
purity ”pure for analysis” and ”chemically pure”.
Results: Duble cast method was applied to identify the exact mass of hydrophobic (cocoa butter, suppocire) and hydrophylic (polyethylene glycol mixtures)
excipients. All the formulated suppositories were subjected to quality tests and showed acceptable physical characteristics and uniformity of drug contents.
The UV-VIS spectrophotometric method for quantitiative determination of furazidine was developed and validated. The validation results showed that
the developed method is simple, fast, accurate and robust.
Conclusions: Suppositories with furazidine were prepared by classic technological methods. Preparation of the suppositories with furazidine on cocoa
butter excipient is a suitable alternative for individual medicinal prescriptions. The UV-VIS spectrophotometric dosing method for furazidine in
suppositories was developed and validated.
