Abstract:
Introduction. Antimicrobial resistance (AMR) is one of the most serious global public
health threats. AMRit is also listed as important scientific, health and economic challenges
and in the absence of some urgent action to address specific diseases the world will face
an alarming threat in the following years. Analyzed studies and World Health Organization reports showed that the use of broad-spectrum antimicrobials for treatment of invasive infections has resulted in an increase in AMR. The emergence and spread of bacteria
resistance can be associated with many factors, but they always represent an evolution
process: a response to selective pressure. As a consequence, the treatment of such infections is becoming increasingly difficult leading to treatment failures and increased mortality.
Antimicrobial stewardship programs (ASP) effective suppose treatment for patients with
bacterial infection, evidence and information to educate and support professionals and
patients to reduce unnecessary use and minimize collateral damage.
Material and methods. The objective of the study was to carry out an analysis of the
literature related antimicrobial resistance, antibiotic stewardship programs. The bibliographic search was made using internet search medical databases as Medline and Scopus,
as well as through the other relevant. We review evidence of progress with these aims in
Europe and nationally in Republic of Moldova.
Results. Excessive and inappropriate use of antimicrobial medicines and poor infection
control practices has transformed AMR into a serious threat to public health worldwide.
If trends continue, we would revert to on world where simple infections are no longer
treatable. AMR is driven by the continued use of antimicrobials, and it is unlikely that the
threat of resistance can be effectively mitigated by the discovery of new antimicrobials
Surveillance is a crucial factor in creating a path to reach the effects caused by resistance.
The integration of the data regarding AMR is desperately needed not only at regional, national but also at global level. Antimicrobial stewardship promotes the judicious use of
antimicrobials to limit the development of AMR.
In the hospital setting, are required infection control measures and ASP administered by
multidisciplinary teams of experts such as infectious diseases physicians, clinical pharmacists, clinical microbiologists, etc. ASP support coordinated interventions designed to improve and measure the appropriate use of antimicrobials including selection, dosing, duration of therapy and route of administration.
Conclusions. Antimicrobial resistance is now recognized by the scientific community, the
society at large and most policy-makers as an important problem to confront. Clinicians,
microbiologists, pharmacists, researchers and the general public must share all the available data on antimicrobials, infections, therapy and information regarding public health
threat of AMR.
