Particularităţi clinico-biologice in reacţii alergice medicamentoase

Abstract

Allergic reactions to drugs most frequently are registered in female patients and younger than 35 and 51-65 years. Antibiotics and nonsteroidal anti-inflammatory drug allergies occur most frequently. In most cases allergic reactions prove less prevalent organ-related and generalized allergic reactions. The most common clinical manifestations were predominantly organ-related ones, cutaneous (69%) and pulmonary manifestations (12%). Blood changes were certified as leukocytosis, lymphocytosis, anemia, eosinophilia, thrombocytopenia.

Reacţiile alergice la medicamente mai frecvent se atestă la pacienţi de gen feminin şi la vârste sub 35 şi 51-65 ani. Antibioticele şi antiinflamatoarele nonsteroidiene produc cel mai frecvent alergie medicamentoasă. În majoritatea cazurilor se atestă reacţii alergice predominante de organ şi mai rar reacţii alergice generalizate. Cele mai frecvente manifestări clinice cu predominanţă de organ au fost manifestările cutanate (69%) şi pulmonare (12%). Modificările hematologice atestate au fost leucocitoza, limfocitoza, anemia, eozinofilia, trombocitopenia