Tumori maligne multiple la pacienţii cu limfomul Hodgkin

Abstract

The second malignant tumours were revealed in 65 (4,2%) cases of 1549 Hodgkin’s disease patients. In 5 cases the concomitant development of them was present. In another 10 cases Hodgkin’s disease was a metachronous neoplasm as to seven primary solid tumours and three chronic limphoprolipheratic disease. The second malignant tumours developed in 50 cases of Hodgkin’s disease in patients 3-30 years after being treated. Only one patient of these had acute myeloblastic leukemia 3,5 years after Hodgkin’s disease treatment with chemoradiotherapy. The second solid malignancies were present in the remaining 49 patients. Their localization was various.

Din 1549 de cazuri de limfom Hodgkin, la 65 (4,2%) de bolnavi au fost depistate tumori secundare maligne. La 5 pacienţi dezvoltarea lor a fost sincronă. În 10 cazuri limfomul Hodgkin s-a dezvoltat metacron faţă de alte 7 tumori primare solide şi trei maladii limfoproliferative cronice. În 50 de cazuri tumorile secundare maligne s-au dezvoltat după 3-30 ani de la tratamentul limfomului Hodgkin. Numai la un pacient după 3,5 ani de la tratamentul combinat chimioradioterapeutic s-a diagnosticat leucemie acută mieloblastică. La ceilalţi 49 de bolnavi sau dezvoltat tumori secundare solide. Localizarea lor a fost variată. La 5 bolnavi s-au înregistrat câte 2-3 tumori secundare maligne.