Contemporary treatment of metabolic and inflammatory diseases of kidney and urinary ways

Abstract

Introduction. The problem of an adequate lavage of kidneys and urinary ways, regardless the new diuretic drugs that invaded the market, is still accute. A modern, effective drug shold have a detoxicating, antiseptic, spasmolytic, antyinflammatory, proteolytic action on the urinary tube formed of renal pelvis and calyces, ureter, bladder, and urethra. Objective. The present research has the objective to analyze the treatment results of two groups of patients with kidney and urinary ways inflammatory and metabolic diseases (I.M.D). Methods and Factual Material. A group of 22 patients with inflammatory and metabolic diseases underwent a classical treatment with anty-inflammatory, spasmolytic, detoxicating, etc. drugs and Nephroclins (drug produced by New Spirit Naturals Co., USA & Vitamax XXI century branch) twice a day for 30 days, and were compared with the control group of 30 patients who underwent the usual treatment only. All the patients were subject to monitoring of dysuria, pollakiuria, pain, feebleness, lack of appetite, and Jordano‘s sign before and after the treatment, as well as patients‘ subjective assessment of their own estate with number 1- as being fully comfortable and 5 - as feeling un comfortable and having numerous com plains. A comparative analyzis of the results of patients‘ tests from both groups, namely blood, urine, creatinine, bilirubin, alanine and asparagine transaminase examination, was undertaken. Then, kydneys‘ estate was studied using renography, chromocystoscopy, echography, and i.v urography. Patients from both groups underwent microbial adhesion test (MAT). Patients with no pyuria, hematuria, and epithelium that did not exceed the acceptable threshold followed De-Almeida test. Test results before and after drug taking were recorded using a previously drawn up form. Results. Comparative study of clinical signs monitoring and subjective estate of the patients in both groups, showed good efficacy all 22 patients from the basic group with inflammatory and metabolic diseases, including those with obstructive pyelonephritis and internal bladder obstruction. 8 patients from the control group had persisting urologic signs. Clinic and laboratory tests showed improval of clinical indexes in 20 out of 22 patients, and in 19 out of 30 patients in control group. The functional estate of kidneys has also improved in 17 out of 22 patients, and in 18 out of 30 patients respectively. It is interesting that microbialadhesion test was negativ in all patients from the first group and in 19 patients out 30 in the control group. No side effects in patients of the first group who took the drug were found. Conclusions. The comparative study that was carried out firstly, shows an important efficacy of Nephroclins in the treatment of inflammatory and metabolic diseases of the kidney and urinary ways. Secondly, the drug proves its efficacy both in patients with obstructive and non-obstructive diseases. And thirdly, none of the patients was victim of drug‘s side-effects.