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Particularities of tissue regeneration of decellularized bovine pericardium xenografts used in the reconstruction of the anterior abdominal wall defects in the experimental model

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dc.contributor.author Negru, I.
dc.date.accessioned 2022-05-13T12:26:42Z
dc.date.available 2022-05-13T12:26:42Z
dc.date.issued 2017
dc.identifier.citation NEGRU, I. Particularities of tissue regeneration of decellularized bovine pericardium xenografts used in the reconstruction of the anterior abdominal wall defects in the experimental model. In: Moldavian Journal of Pediatric Surgery. 2017, no. 1, pp. 71-76. ISSN 2587-3229. en_US
dc.identifier.project https://sncprm.info.md/journal
dc.identifier.issn 2587-3210
dc.identifier.issn 2587-3229
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/20690
dc.identifier.uri https://sncprm.info.md/journal
dc.description.abstract The purpose of this study was to evaluate the regeneration potential of decellularized bovine pericardium grafts used as an option to close the abdominal wall defects in the experimental model. The study group consisted of pigs subjected to reconstructive surgery of congenital abdominal wall defects (group 1 - 3 animals) (fig. 1) and total defect of the abdominal wall created surgically (involving all layers, including the peritoneum) with decellularized bovine pericardium (group 2 - 3 animals). Animals were sacrificed and investigated 30 days (3 animals) and 90 days after surgery (3 animals). he results of this experimental study have allowed us to conclude the following: - The acellular bovine pericardium graft is characterized by strength and durability, favorable for the reconstruction of major abdominal wall defects. - In the regenerative-reparative processes of the acellular bovine pericardium grafts used in the reconstruction of the abdominal wall defects together with fibrogenesis processes, there are also processes of metaplasia with differentiation in chondroblasts which induce the neoformation of cartilage foci in the biological implant, which, then functions as an enchondral ossification factor with the formation of trabecular osteogenesis and ossification foci. - The results obtained imply the need for further studies to clarify the role of these changes in the development of potential follow-up postoperative complications. en_US
dc.language.iso en en_US
dc.publisher National Society of Pediatric Surgery of the Republic of Moldova en_US
dc.relation.ispartof Moldavian Journal of Pediatric Surgery en_US
dc.subject abdominal wall defects en_US
dc.subject biological grafts en_US
dc.subject extracellular matrix en_US
dc.subject bovine pericardium en_US
dc.subject biocompatibility en_US
dc.title Particularities of tissue regeneration of decellularized bovine pericardium xenografts used in the reconstruction of the anterior abdominal wall defects in the experimental model en_US
dc.type Article en_US


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