Abstract:
Background: In this study, the synthesis and characterization of chitosan polymeric materials grafted with nitrofuran derivatives – furaceline and isofural
in terms of antibacterial properties and prolongation of their action were performed.
Material and methods: Synthesis of chitosan analog polymers with maleic anhydride was performed, followed by grafting of nitrofuran derivatives using
ethyl chloroformate. The chemical composition of the obtained polymers was confirmed by FT-IR spectroscopy. Antibacterial study has been performed
on a wide range of Gram-positive and Gram-negative microorganisms.
Results: Chitosan derivatives with a content of 30 mol% of maleic anhydride were obtained. To the analogous polymer ”chitosan maleinized” the medicinal
products isofural or furaciline with the help of the ethyl chloroformate were functionalized. By comparative analysis of the IR spectra of the final products
with the IR spectra of maleinized chitosan and furacilin or isofuran was demonstrated the individual structure of the polymeric preparations “maleinized
chitosan grafted with furacilin“ / “maleinized chitosan grafted with isofural”. The antibacterial substances, isofural and furaciline, among nitrofurans,
being grafted with chitosan maleinized, keep their bactericidal activity in the limits of 75-300 µg/mL. The polymeric materials from chitosan maleate
grafted with isofural or furacillin in a ratio of 70:30 have a prolonged antibacterial action (observation period 72 hours).
Conclusions: It has been found that isofural and furacilin, among nitrofurans, being grafted on chitosan polymeric material, retain their bactericidal
activity and possess prolonged antibacterial action.
