dc.contributor.author |
Rotaru, Larisa |
|
dc.date.accessioned |
2023-05-02T11:41:10Z |
|
dc.date.available |
2023-05-02T11:41:10Z |
|
dc.date.issued |
2023 |
|
dc.identifier.citation |
ROTARU, Larisa. Metabolic syndrome in patients with gout. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2023, vol. 10(1), pp. 22-27. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2023.1.04 |
en_US |
dc.identifier.issn |
2345-1467 |
|
dc.identifier.uri |
https://cercetare.usmf.md/sites/default/files/inline-files/MJHS_10_1_2023.pdf |
|
dc.identifier.uri |
https://doi.org/10.52645/MJHS.2023.1.04 |
|
dc.identifier.uri |
http://repository.usmf.md/handle/20.500.12710/24142 |
|
dc.description.abstract |
Introduction. The definition of metabolic syndrome is not yet consistent. However, many studies have been conducted
in the latest decades about the effect of increased uric acid on metabolic syndrome development. Large epidemiological
studies on the association between hyperuricemia and MS showed that increased concentration of serum urea is often observed in subjects with metabolic syndrome. The aim of the study was to characterize specific dysmetabolic changes and
features of extraarticular evolution in patients with gout.
Materials and methods. A descriptive study was conducted that included 501 patients with gout. The mean age of gout
(423 men and 78 women) was 49.2 (36.9; 59.9). The diagnosis of gout was established according to the classification criteria for gout ACR/EULAR 2015. The raw data was processed in SPSS version 26.0.
Results. According to our data, the highest severity of obesity and LDL-cholesterol was detected in those with tophaceous
gout, which also caused an increase in the frequency of high blood pressure and type 2 diabetes, with age differences in
the frequency of detection of metabolic syndrome and insulin resistance. Our data have noted that serum levels of uric
acid correlated with the risk of developing both metabolic syndrome as well as its components - obesity, hypertension, and
dyslipidemia, but inversely correlated with hyperglycemia.
Conclusions. Gout is associated with a severe lipid metabolism dysfunction, significantly increasing the rate of metabolic
syndrome especially among patients with chronic tophaceous gout, than in the group of patients with gout under the age
of 59 years. On the other hand, in patients with the onset of gout who are ≤59 years lipid metabolism disorders occur significantly earlier than in patients with the onset of gout at the age of ≥60 years. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
en_US |
dc.relation.ispartof |
Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences |
en_US |
dc.subject |
gout |
en_US |
dc.subject |
metabolic syndrome |
en_US |
dc.subject |
dyslipidemia |
en_US |
dc.subject.ddc |
UDC: 616-056.527:616-002.78 |
en_US |
dc.title |
Metabolic syndrome in patients with gout |
en_US |
dc.type |
Article |
en_US |