Abstract:
Abstract.
Introduction. Identification, study and testing of new
remedies for treatment approaches of diseases, resulting
from imbalance between oxidants and antioxidants in favor of oxidants, with potentially destructive potential and
pathogenesis in liver disorders is of particular interest due
to the increase in incidence and severity of these pathologies.
Material and methods. The action of novel local copper
coordination compounds, thiosemicarbazide derivatives -
CMD-4, CMJ-33 and CMT-67, was evaluated in experiments
on white rats after subcutaneous administration in two
different doses (0.1 and 1.0 µM/kg) 3 times a week for 30
days. The main indices of oxidative stress were evaluated:
the level of malonic dialdehyde (MDA), nitric oxide derivatives (NO), S-nitrosothiols, advanced glycation end products
(AGEs), advanced oxidation protein products (AOPP) and
ischemia-modified proteins (IMP), and antioxidant system:
- superoxidismutase (SOD) and catalase activity (CAT), the
level of histidine (His) and total antioxidant activity (TAA) in
liver tissue of white rats.
Results. The administration of CC resulted in the reduction of oxidative stress indices - MDA, AGEs and S-nitrosothiols, which denotes the antioxidant effect of the studied
compounds. The level of NO and AOPP derivatives does not
change substantially. When administering CMD-4 (1 µM/kg),
SOD activity and catalase function decreased markedly.
Changes in the content of His and TAA have been shown to
be inconclusive, maintaining within the limits of the values
recorded in the control group.
Conclusions. The elucidation of the modifications of the
free radicals processes in liver tissues, which are the basis of
the CC action, broadens the theoretical knowledge about the
biological properties of a number of chemical compounds;
as well provide new possibilities to explore perspective objects in order to obtain new efficient drug preparations.
