Abstract:
Abstract
Introduction. Despite numerous fundamental clinical
studies on the frequency, pathogenesis, clinical features
of spondyloarthritis (SpA) in intestinal infectious diseases
(IID) and intestinal damage in SpA, there are currently a
number of unresolved problems, one of which is the problem of early diagnosis of arthropathies, especially associated with IID, which makes it necessary to continue the research in the scientific problem.
Purpose of the study. Appreciation of the features of
early manifestations of axial arthropathies in intestinal infectious diseases in order to improve their early diagnosis.
Objectives of the study. Identification of clinical variants of axial arthropathies in patients with infectious intestinal diseases and instrumental description of axial lesion
by conducting comparative analysis of clinical and laboratory parameters in these patients depending on the presence
of axial arthropathies. Development of an algorithm for the
early detection of axial spondyloarthritis in intestinal infectious diseases.
Material and methods. During 2015-2021, 141 patients
were analyzed retrospectively, out of which 50 patients with
SpA from the Republican Clinical Hospital „Timofei Moşneaga” and 91 patients with infectious intestinal diseases
from the gastro-enterology and hepatology departments
of the Republican Clinical Hospital „Timofei Moşneaga”. Depending on the etiology of IID, subjects were divided into 2
groups: the first group included patients with Yersinia enterocolitica or Campylobacter jejuni (Y±C), the second with
Salmonella enteritidis or Shigella flexneri (S±Sh).
Results. In patients with IID, the following clinical variants of arthropathies have been identified: axial lesion (spinal inflammatory pain according to ASAS criteria (2009)
in 42.9%, axial spondyloarthritis (axSpA) in 28.6%, AS in
15.4%), arthralgia - 38.5%, arthritis - 13.2%. Conventional radiography imaging and magnetic resonance imaging
(MRI) of the sacroiliac joints (SI) increased the incidence of
SpA from 6.6% (n = 6) to 28.6% (n = 26).
Conclusions. In patients with IID, the following clinical
variants of arthropathies have been identified: axial lesion
(spinal inflammatory pain according to ASAS criteria (2009)
in 42.9%, axSpA in 28.6%, ankylosing spondylitis in 15.4%),
arthralgia – 38.5%, arthritis – 13.2%. Imaging in the form of
conventional radiography and MRI of SI joints increased the
incidence of SpA from 6.6% (n = 6) to 28.6% (n = 26). Axial
arthropathies, arthralgia, arthritis, and uveitis are encountered more frequently. At the same time, the possibility of
detecting axSpA is greater if arthritis, arthralgia, inflammatory back pain, uveitis is present. Patients with S±Sh have a higher chance of developing axSpA compared to patients
with Y±C.
