Evaluation of topical remedies in the treatment of acne available in the Republic of Moldova

Abstract

Summary Introduction. A lot of research and studies are currently being carried out in the field of elaboration and optimization of topical pharmaceutical forms used in the treatment of various types of acne. Acne vulgaris is a disease with a complex etiopathogenesis with potential negative psychosocial effects on the quality of life of patients, and its prevention is based on the successful management of risk factors. There are currently many topical and systemic treatment options available, so the choice of therapy depends on the form and severity of the condition. The advantage of topical pharmaceutical forms is the ability to target early stages of acne lesions. Material and methods. Statistical, systemic, informational and sociological analysis were used as methods of analysis. Documentation with the State Drug Nomenclature and Classification, evaluation of topical prescription for acne treatment, dispensed in the Vasile Procopisin University Pharmaceutical Center (UPhC), the study of active pharmaceutical ingredients (API) and technological characteristics of topical pharmaceutical forms. Results. Topical treatment for acne should be based on its type and severity. The basic therapy for the treatment of mild acne refers to external applications, due to their action to prevent lesions. Treatment should be maintained over time to prevent recurrence. For domestic patients are accessible drugs with keratolytic, bacteriostatic and anti-inflammatory properties for topical treatments as benzoyl peroxide, salicylic acid, sulfur, azelaic acid, zinc oxide and antibiotic. The analysis of the use of anti-acne medications, in treating mild to moderate acne, by the age group, identified that for adolescents treatment is being focused on combating the causative agent of sebum production using salicylic acid in 32.5% cases and with age increase, the aim is to suppress inflammatory processes requiring retinoids, and in case of absence, can be substituted by benzoyl peroxide. Conclusions. The therapeutic approach in clinical practice must be done individually, considering the severity and shape of acne lesions.