Abstract:
Abstract.
Introduction. Vitamin D plays an important role in
maintaining musculoskeletal health. As the glomerular filtration rate decreases, vitamin D deficiency also occurs. The
aim of this paper is to highlight the level of vitamin D depending on the stage of chronic kidney disease.
Materials and methods. A structured search was performed in the PubMed, Scopus and HINARI databases,
where the relevant articles have been taken into account,
published in the last 20 years. The search terms used (in
English) were: „vitamin D deficiency”, „pathogenesis of vitamin D”, ”the impact of vitamin D in chronic kidney disease”,
„chronic kidney disease”.
Results. Several studies have shown that the change in
vitamin D levels is dependent to the decrease of glomerular
filtration rate. The lowest serum vitamin D concentration
was observed in stage 5 of chronic kidney disease. Vitamin D deficiency occurs due to a decrease in the number of
nephrons and a decrease in the number of proximal tubular
cells that absorb vitamin D (25 (OH) D) to be subsequently
hydroxylated to its active form by 1α-hydroxylase.
Conclusions. Patients with vitamin D-deficient due to
chronic kidney disease have an increased risk of decreased
bone mineral density and multiple fractures.
