Abstract:
Abstract.
Introduction. The incidence and prevalence of gout
have increased worldwide in recent decades. Scientists at
the Rochester Epidemiology Project (MN, USA) have seen a
two-fold increase in the incidence of primary gout (patients
without diuretic exposure) over a 20-year period, which ended in 1996. The increase of incidence may be related due to
the difficulty and often unsatisfactory treatment options. The
aim of the study was to systematize the recommendations on
dietary treatment, and medication for patients with gout.
Materials and methods. An analytical, qualitative, and
secondary study was performed in the form of a synthesis
article. 115 sources were identified and analyzed; from this
list, 44 sources were selected according to the impact score
during the publication period and according to the level of
recommendations.
Results. 44 articles were included. Most studies were
small, retrospective analyses performed in single centers, with concerns for bias. Eleven studies (including five
randomized controlled trials) reported improved patient
outcomes following pharmacological interventions with
known efficacy in gout, including allopurinol, prednisolone,
NSAIDs and anakinra. Eight studies reported improved outcomes associated with non-pharmacological interventions:
inpatient rheumatology consultation and a hospital gout
management protocol. No studies to date have prospectively evaluated strategies designed to prevent re-admissions of
patients hospitalized for gout flares.
Conclusions. Urate crystals is completely soluble when
we can lower the serum level of uric acid to normal values,
but this often requires long-term treatment. The early onset
of rehabilitation of affected joints helps to reduce the articular inflammatory process, the pain syndrome and it delays
the progression of the underlying pathology while improving the quality of life in patients with gout. Further research
is needed to enable healthcare providers to individualize
and optimize gout treatment strategies, ensuring that patients with gout receive effective, safe, and high-quality care.
