Abstract:
Abstract.
Introduction. An attempt was made to detect the pathogenetic factors involved in the occurrence of the disease by
studying the clinical and laboratory data of 160 patients diagnosed with chronic osteomyelitis of the jaws treated in
the clinic of oro-maxillo-facial surgery between 2005 and
2022. The patients studied were or are still drug users who
use illicitly produced (amphetamine-type drugs) or other
drugs (abbreviated α-PVP). We obtained positive results in
the treatment of toxic osteomyelitis of the jaws following
the implementation of a conservative and surgical treatment scheme.
Materials and methods. Detailed anamnesis of disease
development, clinical examination, pictures, an orthopantomogram, general blood analysis and biochemical profile,
urine analysis, blood markers, and AIDS analysis.
Results. The study of the composition of used substances is an important factor in the definition and development
of the given disease’s cause and mechanism. According to
the patient’s statement, this disease developed following the
use of the amphetamine drug. This drug contained the main
substance – ephedrine, and also red phosphorus and iodine,
which accumulate and cause trophic changes. Almost all organisms’ systems are affected by amphetamine intoxication.
Given that only surgical treatment has a small effect on any
of the patients in this group, we devised a conservative presurgical treatment plan. We prescribe medication for these
patients: detoxification of the body from drugs that cause
spasm of small blood vessels and accumulate in bone tissue, causing necrosis. Lavages of the mouth cavity are performed daily, and necrectomy is eventually performed.
Conclusions. Assistance to drug addicts with jaw necrosis is a demanding subject given that the majority of their
population is unemployed and without insurance. According to unofficial data, there are only 5000 such patients in
Chisinau.
