Abstract:
THE RESEARCH CONCEPTUAL FRAMEWORK.
Relevance and importance of the investigated issue. Currently, oncological diseases
represent an ongoing challenge in modern medicine. The research of new drugs with anti-neoplastic
activity is a major task of modern medicinal chemistry [1, 2]. One of the most significant issues in
treating neoplastic diseases is the high toxicity of chemotherapeutic agents. To date, there are known
several hundred efficient antitumor agents used to treat various malignant pathologies, and nearly
all of these compounds used in clinical practice are non-selective and toxic [2, 3, 4].
In recent years, special attention has been given to Schiff bases - important chemical
compounds that have found wide applications in various fields such as inorganic, analytical, and
medical chemistry due to their ability to form numerous stable complexes when coordinated with
transition metal ions [9]. [...]
