The metabolic effects of native bioactive compounds with antitumor activity: Summary of doctoral thesis in medical sciences: 315.01 - Medical biochemistry

Abstract

THE RESEARCH CONCEPTUAL FRAMEWORK. Relevance and importance of the investigated issue. Currently, oncological diseases represent an ongoing challenge in modern medicine. The research of new drugs with anti-neoplastic activity is a major task of modern medicinal chemistry [1, 2]. One of the most significant issues in treating neoplastic diseases is the high toxicity of chemotherapeutic agents. To date, there are known several hundred efficient antitumor agents used to treat various malignant pathologies, and nearly all of these compounds used in clinical practice are non-selective and toxic [2, 3, 4]. In recent years, special attention has been given to Schiff bases - important chemical compounds that have found wide applications in various fields such as inorganic, analytical, and medical chemistry due to their ability to form numerous stable complexes when coordinated with transition metal ions [9]. [...]