Intoducere. Utilizarea pe scară largă a preparatelor antimicrobiene
în profilaxia și tratamentul infecţiilor septicopurulente
nosocomiale (ISPN) a condus la apariţia tulpinilor
polirezistente la antibiotice. Infecţiile produse de microor-ganisme rezistente reprezintă o problemă majoră pentru sănătatea
publică, determinând un nivel înalt de morbiditate şi
mortalitate, eşecuri terapeutice.
Material și metode. Cercetarea dată reprezintă un studiu
epidemiologic descriptiv, transversal, care se bazează pe metoda
de analiză retrospectivă a 2013 tulpini, izolate de la pacienţii
cu ISPN în Spitalului Clinic de Traumatologie şi Ortopedie,
examinate pe parcursul anilor 2009-2010 și 2013-2014. Studierea
antibioticorezistenţei/sensibilităţii microorganismelor
a fost realizată în laboratorul bacteriologic al Spitalului Clinic
de Traumatologie şi Ortopedie prin metoda disc difuzimetrică.
Rezultate. Sensibilitatea/rezistenţa agenţilor cauzali în infecţiile
septico-purulente de profil ortopedie și traumatologie
este variată, iar valorile acestor parametri diferă în funcţie de
grupul antibioticului, variind de la 29,0 până la 97,0% de probe
sensibile şi viceversa, de la 26,0 până la 98% de probe rezistente.
O pondere mai înaltă a antibioticorezistenţei a fost înregistrată
la microorganismele gramnegative (57,72%), precum și la
tulpinile izolate în asocieri de microorganisme (67,0%), mai cu
seamă, faţă de grupurile preparatelor antimicrobiene larg utilizate
în practica medicală – cefalosporine (66,15%), peniciline
(63,95%) și sulfamide (70,77%).
Concluzii. Agenţii cauzali în patologia septico-purulentă
de profil ortopedie și traumatologie, poartă un caracter polietiologic
şi manifestă rezistenţă înaltă faţă de antibiotice, iar
evitarea eșecurilor terapeutice pot fi prevenite, doar luând în
calcul rezultatele antibioticogramei. Rezultatele studiului confirmă
necesitatea elaborării şi implementării programului de
achiziţionare și utilizare raţională a preparatelor antibacteriene,
supraveghere şi control a antibioticorezistenţei microbiene,
adecvat staţionarului medical.
Intoduction. The widespread use of antimicrobial drugs
in the prophylaxis and treatment of septic-purulent nosocomial
infections (SPNI) led to the appearance of poly resistant
strains to antibiotics. Infections caused by resistant micro-maorganisms
are a major public health problem, determining a
high level of morbidity and mortality treatment failures.
Material and methods. This research is an epidemiological,
descriptive, transversal study, based on retrospective analysis
method of the 2013 strains, isolated from patients with
SPNI in Clinical Hospital of Orthopedy and Traumatology, examined
in 2009-2010 and 2013-2014. Antibiotics resistance/
sensitivity of the microorganisms study has been achieved in
the bacteriological laboratory of the Clinical Hospital of Orthopedy
and Traumatology, using disk diffusion method.
Results. Sensitivity/resistance of the causative agents in
septic purulent orthopedic and traumatic infections is varied,
and the values of these parameters vary depending on the antibiotic
group, ranging from 29.0 up to 97.0% – sensitive samples,
and vice versa, from 26.0 to 98% – resistant samles. A
higher share of antibiotics resistance was recorded in gramnegative
microorganisms (57.72%), as well as – in isolated
strains microorganisms associations (67.0%), especially the
groups of antimicrobial preparations. widely used in medical
practice – cephalosporin (66.15%), penicillin (63.95%) and
sulfamide (70.77%).
Conclusions. Causative agents in orthopedic and traumatic
septic-purulent pathology has a polyetiologic character and
exhibit high resistance to antibiotics and avoidance of treatment
failures can be prevented, only taking into account the
results of antibiotic resistance. The study results confirm the
necessity to develop and implement the program of acquisition
and rational use of antibacterial drugs, supervision and
control of microbial antibiotics resistance, appropriate to the
medical station.
Intoduction. The widespread use of antimicrobial drugs
in the prophylaxis and treatment of septic-purulent nosocomial
infections (SPNI) led to the appearance of poly resistant
strains to antibiotics. Infections caused by resistant micro-maorganisms
are a major public health problem, determining a
high level of morbidity and mortality treatment failures.
Material and methods. This research is an epidemiological,
descriptive, transversal study, based on retrospective analysis
method of the 2013 strains, isolated from patients with
SPNI in Clinical Hospital of Orthopedy and Traumatology, examined
in 2009-2010 and 2013-2014. Antibiotics resistance/
sensitivity of the microorganisms study has been achieved in
the bacteriological laboratory of the Clinical Hospital of Orthopedy
and Traumatology, using disk diffusion method.
Results. Sensitivity/resistance of the causative agents in
septic purulent orthopedic and traumatic infections is varied,
and the values of these parameters vary depending on the antibiotic
group, ranging from 29.0 up to 97.0% – sensitive samples,
and vice versa, from 26.0 to 98% – resistant samles. A
higher share of antibiotics resistance was recorded in gramnegative
microorganisms (57.72%), as well as – in isolated
strains microorganisms associations (67.0%), especially the
groups of antimicrobial preparations. widely used in medical
practice – cephalosporin (66.15%), penicillin (63.95%) and
sulfamide (70.77%).
Conclusions. Causative agents in orthopedic and traumatic
septic-purulent pathology has a polyetiologic character and
exhibit high resistance to antibiotics and avoidance of treatment
failures can be prevented, only taking into account the
results of antibiotic resistance. The study results confirm the
necessity to develop and implement the program of acquisition
and rational use of antibacterial drugs, supervision and
control of microbial antibiotics resistance, appropriate to the
medical station.
