Introducere. Existenţa unei game variate de medicamente utilizate pentru diferite afecţiuni somatice sau psihiatrice este asociată cu riscul apariţiei unor efecte adverse care limitează aderenţa şi conformitatea la aceste terapii medicamentoase, determinând frecvent sistarea medicamentaţiei. Acest fenomen poate declanşa sindromul de discontinuare sau inconsecvenţa terapeutică, responsabil de diminuarea eficacităţii terapiilor medicamentoase. în acelaşi timp, noi considerăm că apariţia şi intensitatea efectelor adverse sunt dependente de o vulnerabilitate genetică de tip latent sau spectral. Scopul lucrării. Scopul acestei lucrări este de a investiga aplicarea sistemică a oxigen-ozonoterapiei în gestionarea efectelor adverse ale terapiilor medicamentoase. Material şi Metode. Aplicarea sistemică a oxigen-ozonoterapiei. Rezultate. Astăzi, apariţia unui efect advers indus de un medicament poate însemna dezvoltarea unei vulnerabilităţi genetice mai sus menţionate. Majoritatea efectelor adverse sunt asociate cu disfuncţia mitocondrială şi stresul oxidativ, mecanisme patogenice de tip celular ce pot fi controlate de terapia cu oxigen-ozon. Concluzii. Terapia cu oxigen-ozon poate reprezenta o modalitate eficientă de gestionare a efectelor adverse ale terapiilor medicamentoase, având capacitatea de a influenţa disfuncţia mitocondrială şi stresul oxidativ, susceptibile de a fi implicate în etiologia acestor efecte adverse.
Introduction. The existence of a wide range of medications used for various somatic or psychiatric conditions is associated with the risk of developing adverse effects that limit adherence and compliance to these drug therapies, often leading to medication discontinuation. This phenomenon can trigger withdrawal syndrome or therapeutic inconsistency, responsible for reducing the effectiveness of drug therapies. At the same time, we consider that the occurrence and intensity of adverse effects are dependent on a latent or spectral type of genetic vulnerability. Aim of the Study. The aim of this study is to investigate the systemic application of oxygen-ozone therapy in managing the adverse effects of drug therapies. Material and Methods. Systemic application of oxygen-ozone therapy. Results. Today, the occurrence of an adverse effect induced by a medication may signify the development of the aforementioned genetic vulnerability. Most adverse effects are associated with mitochondrial dysfunction and oxidative stress, cellular pathogenic mechanisms that can be controlled by oxygen-ozone therapy. Conclusions. Oxygen-ozone therapy may represent an efficient method for managing the adverse effects of drug therapies, with the capacity to influence mitochondrial dysfunction and oxidative stress, which are likely implicated in the etiology of these adverse effects.