Abstract:
Atopic dermatitis (AD) is a multifactorial, heterogenous disease that arises as a result of the interaction between both environmental and genetic
factors. Loss-of-function mutations found within the FLG gene encoding the structural protein, filaggrin, represent the most significant genetic factor
predisposing to AD identified to date. In this article is reviewed the updated one of the genetic factors predisposing to AD, namely, a failure of skin barrier
function undermined by mutations in the fillagrin gene. These genetic defects are responsible for enhanced permeability of the skin for allergens while
epicutaneous sensitization promotes the development of atopic dermatitis.
Description:
Institutul Mamei şi Copilului, Catedra Dermatovenerologie, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu”, Chişinău, Republica Moldova, Congresul V Naţional de Dermatologie cu participare internaţională Chişinău, 9-11 iunie 2016, Chişinău, Republica Moldova
