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dc.contributor.author Gogu, Vladislav
dc.contributor.author Beţiu, Mircea
dc.contributor.author Pârţână, Lucia
dc.contributor.author Nagîţ, Angela
dc.contributor.author Popovici, Svetlana
dc.contributor.author Cucerova, Irina
dc.contributor.author Caisîm, Tatiana
dc.contributor.author Iasincovscaia, Anna
dc.contributor.author Ţâbârnă, Vasile
dc.date.accessioned 2019-06-24T22:41:25Z
dc.date.available 2019-06-24T22:41:25Z
dc.date.issued 2016
dc.identifier.citation GOGU, Vladislav, BEŢIU, Mircea, PÂRŢÂNĂ, Lucia, et al. Manifestările cutaneo-mucoase in infecţia HIV/SIDA = Mucocutaneous manifestations in patients with HIV/AIDS infection. In: Curierul Medical. 2016, vol. 59, no 3, pp. 91-92. ISSN 1875-0666.
dc.identifier.issn 1857-0666
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/2967
dc.identifier.uri http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-3-PDF-1.pdf
dc.description.abstract Generalităţi. Procesul epidemic al infecţiei HIV/SIDA, în Republica Moldova (RM), se află în continuă ascensiune. Astfel, conform datelor statistice, la 01.01.2015, în RM, au fost înregistrate 10 213 cazuri de HIV infectaţi, dintre care diagnosticaţi cu SIDA – 3130 şi deja decedaţi – 2892 de persoane. Ţinând cont de faptul că manifestările cutaneo-mucoase sunt frecvent întâlnite la persoanele HIV infectate, ne-am propus ca scop evaluarea frecvenţei şi particularităţilor clinico-evolutive ale leziunilor dermatologice la pacienţii cu infecţie HIV/SIDA. Material şi metode. Studiul retrospectiv a cuprins 2244 de fişe ale pacienţilor cu diagnosticul HIV/SIDA, internaţi în Spitalul Dermatologie şi Maladii Comunicabile pentru perioada 2011-2014. De asemenea, au fost înregistrate o serie de cazuri clinice mai relevante. Rezultate. Pe parcursul perioadei de referinţă, au fost înregistraţi 1886 de pacienţi cu manifestări cutaneo-mucoase, dintre care valoarea CD4+ sub 200 cel/mmc a fost inregistrată la 881 de pacienţi. Afectarea solitară a mucoaselor a fost estimată la 1383 de pacienţi, afectarea solitară a pielii la 92 de pacienţi şi afectarea combinată cutaneo-mucoasă – la 411 pacienţi. Atingerea mucoasei cavităţii bucale a fost raportată în 96% din cazuri, cu prevalenţa incontestabilă a infecţiei provocate de C. albicans, exprimată prin candidoză orofaringiană sau esofagiană. Evaluarea ponderii atingerilor cutanate la pacienţii HIV infectaţi a evidenţiat prezenţa manifestărilor cutanate infecţioase în 52% cazuri, al manifestărilor non-infecţioase - în 45% cazuri (dintre care mai mult de 2/3 au fost cu dermatoze alergice) şi doar la 3% din cazuri – manifestări neoplazice. Formele clinice ale atingerilor cutaneo-mucoase şi evoluţia lor au corelat cu valoarea numerică a celulelor CD4. Concluzii. Manifestările cutaneo-mucoase se întâlnesc la persoanele HIV-infectate în 84% din cazuri. Mai frecvent, se afectează mucoasa cavităţii bucale. Severitatea şi forma clinică a atingerilor cutaneo-mucoase corelează cu valoarea limfocitelor CD4. În majoritatea cazurilor, leziunile cutaneo-mucoase la pacienţii HIV-infectaţi, apar în urma imunităţii scăzute şi pot fi considerate ca semne revelatoare ale imunosupresiei legate de HIV, fapt care permite identificarea precoce a acestei infecţii. ro
dc.description.abstract Overview. Epidemic evolution of HIV/AIDS in the Republic of Moldova is in a permanent progression. Thus, in accordance with statistic data on 01.01.2015 in the Republic of Moldova 10213 cases of HIV/AIDS were registered, among those 3130 people were identified with AIDS and 2892 have already died. It is well known that mucocutaneous manifestations are not rare in patients with HIV/AIDS this is why authors’ aim was to evaluate frequency and clinico-evolutive peculiarities of skin lesions in patients with HIV/AIDS. Materials and methods. A retrospective research was done, which included 2244 medical files of patients with HIV/AIDS, who have been treated at the Hospital of Dermatology and Communicable Diseases during 2011-2014. A number of relevant clinical cases were described as well. Results. 1886 patients with HIV/AIDS, who have shown mucocutaneous involvement, have been registered during present research, in 881 of them CD4+ count was less than 200cells/mmc. Involvement of mucous membranes was established only in 1383 cases, of the skin only in 92 cases and both mucocutaneous manifestations in 411 patients. Mucous membrane affection was reported in 96% of cases with incontestable prevalence of C. albicans infection manifested by oropharyngeal or esophageal candidiasis. Evaluation of cutaneous involvement in patients with HIV has shown as follows: presence of skin infections in 52% of cases, non-infectious dermatoses in 45% of cases (2/3 of which were allergic skin disorders) and skin tumors in 3% of patients only. Clinical forms of skin diseases and their evolution was in strong correlation with CD4+ cells count. Conclusions. Mucocutaneous manifestations affect patients with HIV/AIDS in 84% of cases. The most frequent target is oral cavity. Severity and clinical forms of mucocutaneous involvement have a strong correlation with CD4+ cell count. In majority of cases, mucocutaneous lesions in patients with HIV occur because of decreased immune response and might be considered relevant signs of immunosupression induced by HIV, as well as comprehensive tool for HIV/AIDS early detection. en
dc.publisher Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” en_US
dc.relation.ispartof Curierul Medical: Congresul V Naţional de Dermatologie cu participare internaţională, 9-11 iunie 2016, Chişinău, Republica Moldova
dc.subject HIV/AIDS infection en_US
dc.subject mucocutaneous manifestations en_US
dc.subject.mesh Acquired Immunodeficiency Syndrome--complications en_US
dc.subject.mesh HIV Infections--complications en_US
dc.subject.mesh Skin Manifestations en_US
dc.title Manifestările cutaneo-mucoase în infecţia HIV/SIDA ro
dc.title.alternative Mucocutaneous manifestations in patients with HIV/AIDS infection en_US
dc.type Other en_US


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