Assessing the impact of MEN syndrome on quality of life

Abstract

Background. Multiple Endocrine Neoplasia (MEN syndrome) is a rare genetic disorder characterized by the development of tumors in the endocrine glands caused by inactivating mutations of the MEN tumor suppressor gene; inherited in a transmission in autosomal dominant tract. There are 3 main types of MEN syndrome: MEN1, MEN2A, and MEN2B. These tumors can affect different endocrine glands such as pancreas thyroid parathyroid and adrenal gland Objective of the study. the evaluation of QOL in MEN patients should attract the attention of the medical community as an important medical aspect to be considered in the management of patients with this complex syndrome. Material and methods. PubMed, Google Scholar, and clinical journals. Results. MEN syndrome has an impact on QOL of the patient who usually experience symptoms such as hypertension hypoglycemia hypercalcemia broken bones peptic ulcer and severe pain. It contributes also to emotional disturbances and depression. The diagnosis of this tumor is a trauma for patients mainly due to the uncertainty of its outcome, adding to the need for frequent medical monitoring and interventions that can disrupt daily life and cause emotional distress. Moreover, the complex nature of managing this disease includes multiple medical interventions surgeries, regular screenings to detect and manage tumor growth and lifelong surveillance. All of this poses significant challenges to maintain a satisfactory QOL, Financial burdens, limitations in daily activities, and disruptions in social relationships contribute to the overall impact on QOL. Conclusion. With all the advancements in medical care nowadays, living with MEN syndrome is a big challenge for every patient and awareness of his quality of life should be considered as an important goal to achieve medical aspect should be considered in the management of patients with this complex syndrome.