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dc.contributor.author Chaima, Ati
dc.date.accessioned 2025-02-07T13:35:11Z
dc.date.available 2025-02-07T13:35:11Z
dc.date.issued 2024
dc.identifier.citation CHAIMA, Ati. Atopic dermatitis and asthma-clinical interconnections. In: Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences. 2024, vol. 11, nr. 3, anexa 2, p. 218. ISSN 2345-1467. en_US
dc.identifier.issn 2345-1467
dc.identifier.uri https://cercetare.usmf.md/sites/default/files/inline-files/MJHS_11_3_2024_anexa2__site.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/30007
dc.description.abstract Introduction. Atopic diseases, such as atopic dermatitis, allergic rhinitis, and asthma have become more prevalent in recent decades, now affecting about 20% of the population in developed countries. The term “atopic march” describes the typical progression of these conditions, starting with atopic dermatitis (AD) in infants and often leading to allergic rhinitis and asthma in children. The purpose: To perform a literature review about clinical interconnection between AD and asthma and about the possibility of progression from AD to asthma and vice-versa. Material and methods: A literature search was performed, using key words “atopic dermatitis, asthma, atopic diseases, atopic march”. We used PubMed database and selected articles published in 2012-2024. During search system identified 715 articles. After selection of most relevant ones published in English, we analyzed 20. Results. AD significantly increases the risk of developing asthma, as evidenced by higher odds ratios in children with AD compared to those without, according to several longitudinal studies. Children with AD who have specific IgE antibodies to common environmental allergens, typically identified by age 2 to 4, are more likely to progress to allergic rhinitis and asthma than those with non-IgE mediated AD. Therefore, extrinsic AD is a more precise indicator of the initial risk for developing other atopic conditions. The key risk factors for the progression and persistence of asthma include early onset of AD, IgE sensitization, and its severity. Approximately 70% of patients with severe AD develop asthma, compared to 20-30% of those with mild AD, and about 8% of the general population. Conclusions. The development of these diseases and their progression is significantly influenced by genetic and environmental factors. It’s very important to identify patients at risk from an early age and to provide a window for early therapeutical strategies. en_US
dc.language.iso en en_US
dc.publisher Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova en_US
dc.relation.ispartof Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences en_US
dc.subject asthma en_US
dc.subject atopic dermatitis en_US
dc.subject atopic march en_US
dc.title Atopic dermatitis and asthma-clinical interconnections en_US
dc.type Other en_US


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