Abstract:
Background. Juvenile idiopathic arthritis (JIA) is one of
the most frequent chronic diseases of childhood, often
persisting into adulthood and can lead to significant longterm morbidity. As a long-standing chronic inflammatory
disease, concerns have been expressed about the risk of
premature cardiovascular disease (CVD) in JIA. Objective
of the study. assessment of traditional cardiovascular risk
factors in patients with juvenile idiopathic arthritis. Material and methods. The research is related to the analysis of
bibliographic sources identified in PubMed, NCBI, Research
Gate, Medline, from the last 10 years. Results. JIA is the
most common chronic inflammatory arthritis in children
and young people, with onset below the age of 16 years and
characterized by pain, swelling and long-lasting joint stiffness. In the pathogenesis and progression of JIA, the imbalance between pro- and anti-inflammatory cytokines may be
involved in the regulation of systemic inflammation, local joint lesions and bone erosion. In the last few decades, there
has been considerable interest in the long-term outcomes
of people with chronic inflammatory arthritis, and one area
of particular interest has been the increased prevalence of
CVD. This increased risk is attributed to a higher prevalence
of traditional CVD risk factors and the role of systemic inflammation in accelerating atherosclerosis. Previous studies have identified an elevation of traditional cardiovascular
disease risk factors in JIA, including family history of cardiovascular disease, hypertension and even smoking history. In
addition, an abnormal lipid profile has been observed. Conclusions. Patients with JIA present with subclinical signs of
inflammation and risk of cardiovascular disease, evidenced
by increased levels of inflammatory cytokines, elevated lipid profile abnormalities involved in impairment of the cardiovascular system.
