Abstract:
Introduction. MALT lymphoma is the most common type of extranodal non-Hodgkin lymphoma. In two-thirds of cases, it
originates in the stomach and is strongly associated with Helicobacter pylori infection. It presents a complex clinical picture, that can resemble multiple conditions, and typically follows a benign course.
Clinical case presentation. This report discusses an uncommon case of a 52-year-old female who presented to the oncologist
with insignificant weight loss, episodes of melena and fatigue. The disease started in 2018 with upper gastrointestinal bleeding from a gastric ulcer caused by H. pylori, which was later eradicated. The patient underwent multiple upper endoscopies
over the years, with no evidence of malignancy. During the most recent investigation, an ulcerated mass of about 20 mm with
infiltration of the adjacent mucosa was found. The biochemical and serological examination was within normal values. Abdominal computed tomography revealed unexplained perigastric and intestinal lymphadenopathy. The patient underwent total
gastrectomy and lymph node dissection due to suspected gastric cancer. Histological and immunohistochemical examinations
confirmed advanced MALT lymphoma with tumour cells positive for cluster of differentiation 45, 20 (CD45, CD20) and B-cell
lymphoma 2 (BCL2). Given the advanced stage of the disease, adjuvant polychemotherapy was also administered, and the patient’s condition improved significantly. Conclusions. MALT lymphoma is a rare condition that requires close attention and a
high index of suspicion, even in unusual cases like the one presented. Endoscopic examination performed by an experienced
specialist, accompanied by proper biopsy and a multidisciplinary team approach increases the survival rate of patients.
