Influence of polymorphic variants of serotonin receptor 5-HTR2AT 102C gene on mental status of patients with rheumatic arthritis depending on sex

Abstract

Background: In this study was determined the frequency of T102C polymorphism of the 5-HTR2A gene and its impact on the mental state of the patients with RA according to sex and gene variant polymorphism. Material and methods: Molecular genotyping was performed using the technique of polymerase chain reaction. The degree of depression severity in the examined according to the Hamilton Anxiety Rating Scale was assessed. The levels of reactive and personal anxiety were defined according to the scale of Spielberger. Results: In the study, we found that in women with RA was significantly less common homozygous СС as compared to male patients (p <0.05), and the clinical picture of patients with RA women with TT and TC genotypes there were significantly more frequent symptoms of fatigue, autonomic anxiety and depressive disorders (DS), high state, trait anxiety and symptoms of severe depression (p <0.001), whereas in women with CC genotype were found mild symptoms of DS. Our results showed that patients with RA men with genotype TC and TT, compared with women’s characteristics, revealed mild to moderate severity of DS, and RA men patients with genotype СС did not demonstrate the symptoms of depression (p <0.05). Conclusions: Depressive disorders with high levels of state and trait anxiety that affect significantly the course and manifestations in women with genotype TC and TT were detected in the vast majority of patients with RA.