Rezumat.
Doza zilnica definita (DDD) recomandata de OMS ca unitate de ma sura
pentru consumul medicamentelor, este un parametru atribuit fieca rei
substant e active din clasificarea ATC (Anatomic/Terapeutic/Chimic)2. I n
spitale, determinarea pentru antimicrobiene a DDD pe 100 de zile (DDD/100
zile) reflecta utilizarea antibioticelor s i chimioterapicelor s i poate da indicii
asupra rezistent ei microbiene pentru anumite clase1. Am determinat
comparativ consumul antimicrobienelor dintr-un spital din Bucures ti, pe o
perioada de 3 ani (2015-2017), iar rezultatele studiului au ara tat diferent e
semnificative î n utilizarea cefalosporinelor din generat ia a treia s i a patra, a
colistinei s i a tigeciclinei. Aceste date sugereaza o cres tere a rezistent ei
bacteriilor din grupele: Enterobacteriaceae, Pseudomonas spp., bacterii gram
pozitive, care pot produce infect ii nosocomiale severe.
Abstract.
Daily Defined Dose (DDD), recommended by WHO as a measure of drug
consumption, is a parameter attributable to every active substance in ATC
(Anatomic/Therapeutic/Chemical) classification2. In hospital setting,
determination of DDD for antimicrobials over 100 days (DDD/100 days)
reflects the use of antibiotics and chemotherapeutics, being able to yield
insight on microbial resistance for certain classes1. We determined
comparatively consumption of antimicrobials in a Bucharest hospital over a
period of 3 years (2015-2017) and the results showed significant differences
in use of third and fourth generation cephalosporins, of colistin and of
tigecyclin. The data suggest an increase in bacterial resistance for the
Enterobacteriaceae, Pseudomonas spp. And Gram-positive groups, all able of
inflicting severe nosocomial infections.