ASPECTELE CLINICO-IMAGISTICE A PACIENŢILOR ÎN DUBLĂ PROVOCARE: COVID-19 ŞI TUBERCULOZĂ

Abstract

Introducere. Pandemia COVID-19 a depăşit în prezent orice altă problemă de sănătate din întreaga lume şi a perturbat succesele în controlul tuberculozei (TB) la nivel global. COVID-19 reprezintă o infecţie ameninţătoare de viaţă, contribuind la o rată înalta de deces din cauza unui sigur agent patogen (SARS-CoV-2). Scop. Analiza şi evaluarea caracteristicilor clinico imagistice la pacienţii diagnosticaţi cu coinfecţia TB/COVID-19, pentru determinarea conduitei cazului de coinfecţie TB/COVID-19. Material şi metode. A fost realizat un studiu retrospectiv pe pacienţii care au urmat tratament în IMSP IP,Chiril Draganiuc,, unde au fost incluşi 80 pacienţi cu coinfecţia TB/COVID-19 (lotul de studiu/LS) şi 113 pacienţi cu TB (lotul de comparaţie/LC) din R. Moldova. Datele obţinute au fost analizate utilizând testul de semnificaţie statistică exact Fisher. Rezultate. A prevalat genul masculin. Toţi pacienţii au prezentat astenie 100%, inapetenţă LS 100%, LC 82%, tusea LS 93%, LC 86%, febra LS 91%,LC 3%, (p<0,05) Concluzii. Caracteristicile clinico-imagistice ale pacienţilor cu coinfecţie TB/ COVID-19 sunt determinate de severitatea manifestărilor sindromul toxico-infecţios şi bronhopulmnar, statutul co-morbid al pacientului, predominarea sindromul de condensare, interstiţial şi sticla mată.

Introduction. The COVID-19 pandemic currently has surpassed any other health problem worldwide and has disrupted the successes in tuberculosis (TB) control globally. COVID-19 represents a life-threatening infection, contributing and promoting to a high rate of death due to a specific pathogen (SARS-CoV-2 virus). Objective. To assess and analysis the clinical and imaging characteristics in patients with TB/COVID-19 co-infection for determining the management of the TB/COVID-19 co-infection case. Material and methods. A retrospective study was conducted in patients who underwent treatment in Chiril Draganiuc Institute of Pneumology, where 80 patients with TB/COVID-19 co-infection (study group/LS) and 113 patients with TB (comparison group/LC) from the Republic of Moldova were included. The data obtained were analyzed using the Fisher’ exact statistical significance test. Results. Male patients prevailed. Clinical signs were asthenia 100%, anorexia SG 100%, CG 82%, cough SG 93%, CG 86%, fever SG 91%, CG 3%, (p<0,05) Conclusion. The clinical and imaging characteristics of patients with TB/COVID-19 co-infection is determined by the severity of the intoxication and bronchopulmonary syndrome manifestations, the patient’s comorbid status, the predominance of the condensation syndrome, interstitial and ground-glass opacity.