Introducere. Reacţiile adverse la medicamente sunt o problemă majoră de sănătate publică, influenţând morbiditatea şi mortalitatea. Farmacistul clinician joacă un rol crucial în identificarea şi gestionarea lor. Integrarea sa în echipe medicale poate reduce incidenţa reacţiilor adverse, îmbunătăţind siguranţa pacienţilor. Scop. Evaluarea rolului farmacistului clinician în detectarea precoce, raportarea riguroasă şi gestionarea eficientă a reacţiilor adverse la preparatele medicamentoase în Republica Moldova. Material şi metode. Studiul a fost unul retrospectiv, descriptiv. Au fost cercetate şi evaluate fişele-comunicare ale reacţiilor adverse recepţionate de Secţia farmacovigilenţă a Agenţiei Medicamentului din Republica Moldova pe parcursul anului 2024. Datele au fost analizate cantitativ, concentrându-se pe tipul medicamentelor implicate şi severitatea reacţiilor. Rezultate. În 2024, au fost recepţionate 277 fişe-comunicare a reacţiilor adverse, incluzând 12 cazuri de ineficienţă a preparatului medicamentos. Majoritatea bolnavilor au manifestat reacţii alergice la antituberculoase (33%) şi medicamente pentru tratamentului infecţiei HIV-SIDA (13%). Cel mai frecvent raportate RA au fost la: antituberculoase (116), antibiotice (30), substanţe de contrast (15), antihipertensive (7), soluţii perfuzabile (27), antiretrovirale (11). Majoritatea RA au fost de gravitate medie (67,55%), iar cele grave au constituit 17,21%, indicând că peste jumătate au avut un caracter periculos pentru sănătatea pacientului. Concluzii. Studiul a confirmat importanţa monitorizării continue a reacţiilor adverse. Implementarea unor programe de far-macovigilenţă, cu implicarea activă a farmacistului clinician, poate contribui semnificativ la îmbunătăţirea siguranţei farmacoterapiei şi la reducerea incidenţei evenimentelor adverse.
Introduction. Adverse drug reactions are a major public health concern, impacting morbidity and mortality. The clinical pharmacist plays a crucial role in their identification and management. Integrating them into medical teams can reduce the incidence of adverse reactions, thereby improving patient safety. Objective. Evaluating the role of the clinical pharmacist in the early detection, rigorous reporting, and efficient management of adverse drug reactions in the Republic of Moldova. Material and methods. This was a retrospective, descriptive study. We analyzed and evaluated adverse reaction communication forms received by the Pharmacovigilance Section of the Medicines Agency of the Republic of Moldova throughout 2024. Data were analyzed quantitatively, focusing on the type of drugs involved and the severity of the reactions. Results. In 2024, 277 adverse reaction communication forms were received, including 12 cases of drug ineffectiveness. Most patients experienced allergic reactions to antituberculosis drugs (33%) and medications for HIV-AIDS infection treatment (13%). The most frequently reported adverse reactions were associated with: antituberculosis drugs (116), antibiotics (30), contrast agents (15), antihypertensives (7), infusion solutions (27), and antiretrovirals (11). The majority of adverse reactions were of moderate severity (67.55%), while serious ones constituted 17.21%, indicating that over half posed a risk to patient health. Conclusion. The study confirmed the importance of continuous monitoring of adverse reactions. Implementing pharmacovigilance programs with the active involvement of clinical pharmacists can significantly contribute to improving the safety of pharmacotherapy and reducing the incidence of adverse events.
