MODIFICĂRI CORNEENE ASOCIATE ADMINISTRĂRII UNOR MEDICAMENTE

Machidon, Maria-Mirabela

dc.contributor.author	Machidon, Maria-Mirabela
dc.date.accessioned	2025-12-06T12:50:28Z
dc.date.accessioned	2025-12-07T15:39:16Z
dc.date.available	2025-12-06T12:50:28Z
dc.date.available	2025-12-07T15:39:16Z
dc.date.issued	2025
dc.identifier.citation	Machidon, Maria-Mirabela. MODIFICĂRI CORNEENE ASOCIATE ADMINISTRĂRII UNOR MEDICAMENTE = CORNEAL CHANGES ASSOCIATED WITH CERTAIN MEDICATIONS. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2025, vol. 12, Nr. 3/2025, anexa 2, p. 308. ISSN 2345-1467.	en_US
dc.identifier.issn	2345-1467
dc.identifier.uri	https://cercetare.usmf.md/sites/default/files/2025-10/MJHS_12_2_2025_anexa2site.pdf
dc.identifier.uri	https://repository.usmf.md/handle/20.500.12710/32039
dc.description	Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”, Chișinău, Republica Moldova	en_US
dc.description.abstract	Introducere. Unele medicamente se pot acumula în corn-ee sau pot altera metabolismul local ducând la modificări vizibile identificate la lampa cu fantă şi microscopia confo-cală. Manifestările corneene în urma administrării medicamentelor pot reflecta potenţial risc de modificări lenticulare sau retiniene. Scop. Evaluarea modificărilor corneene asociate administrării medicamentelor frecvent utilizate în scopul identificării celor cu potenţial toxic ocular în vederea perceperii riscurilor. Material şi metode. Ca materiale au servit publicaţiile ştiinţifice din literatura de specialitate PubMed, Google Scholer, ScienceDirect, Scopus, ResearchGate folosind	ro_RO
dc.description.abstract	Introduction. Some drugs may accumulate in the cornea or alter local metabolism leading to visible changes identified by slit lamp and confocal microscopy. Corneal manifestations following drug administration may reflect potential risk of lenticular or retinal changes the drug history being important. Objective. Evaluation of corneal changes associated with the administration of frequently used medications in order to identify those with ocular toxic potential for risk perception. Material and methods. The materials used were scientific publications from the specialized literature PubMed, Google Scholar, ScienceDirect, Scopus, ResearchGate using	en_US
dc.publisher		en_US
dc.relation.ispartof	Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences	en_US
dc.subject	such as cornea	en_US
dc.subject	drug	en_US
dc.subject	ocular surface. The scientific publications were evaluated during the period 2020-2025	en_US
dc.subject	the data being systematized according to pharmacological class. Results. Systemic medications can reach the cornea through the tear film	en_US
dc.subject	aqueous humor and vasculature. Evaluated studies show a wide range of corneal changes from superficial epilopathy and punctate keratopathy to stromal deposits and irreversible endothelial changes. The most commonly implicated classes of drugs include	en_US
dc.subject	antibiotics	en_US
dc.subject	antivirals and topical anesthetics. Amphiphilic drugs (amiodarone	en_US
dc.subject	chloroquine	en_US
dc.subject	etc.) can produce lipidosis with epithelial or endothelial deposition	en_US
dc.subject	while antimetabolites can lead to degeneration of basal epithelial cells with microcyst formation. Identification is essential to prevent ocular complications. Conclusion. Corneal changes following drug administration may be influenced by dose and their physicochemical properties. Discontinuation of drug administration may be useful for reducing symptoms and requires monitoring in relation to systemic risks of the pathology of the patient	en_US
dc.title	MODIFICĂRI CORNEENE ASOCIATE ADMINISTRĂRII UNOR MEDICAMENTE	ro_RO
dc.title.alternative	CORNEAL CHANGES ASSOCIATED WITH CERTAIN MEDICATIONS	en_US
dc.type	Article	en_US