Abstract:
Structure of the thesis: the thesis is presented on 135 pages of basic text that
includes an introduction, 4 chapters and conclusions. The work cites 305 bibliographic
sources, being illustrated by 47 tables, 31 figures, 4 appendixes. The obtained results
are published in 21 scientific papers.
Key words: community-acquired pneumonia, heart failure, clinical-paraclinical
features, oxidative stress.
Field of study: 321.01 Internal diseases (with specification: Pulmonology).
Aim of the study: assessment of clinical, paraclinical peculiarities, the disease
course and oxidative stress characteristics in community-acquired pneumonia in
patients with chronic heart failure.
Study objectives: assessment of clinical, paraclinical peculiarities and the disease
course in patients with community-acquired pneumonia and concomitant chronic heart
failure; assessment of oxidative stress markers in patients with community-acquired
pneumonia and chronic heart failure; correlation of inflammatory and oxidative stress
indices with clinical and paraclinical data in patients with community-acquired
pneumonia and chronic heart failure; determination of clinical, paraclinical
peculiarities and the disease course in patients with community-acquired pneumonia
and chronic heart failure, depending on the left ventricular ejection fraction and the
functional class of heart failure; analysis of the diagnostic accuracy of communityacquired pneumonia severity scores (PSI/PORT, CURB-65, DS-CRB-65) and
development of a model for predicting the severe progression of community-acquired
pneumonia in chronic heart failure.
Scientific novelty and originality: the clinical-paraclinical and evolutionary data
of community-acquired pneumonia in patients with chronic heart failure were
analyzed, the importance of inflammatory and oxidative stress markers in patients with
community-acquired pneumonia and chronic heart failure was determined.
The scientific problem solved in the thesis: the results of the study allowed the
development of a model to predict the unfavorable outcome of community-acquired
pneumonia in patients with pre-existing chronic heart failure.
The theoretical significance and applied value of the work: the research into
the clinical, paraclinical, and the disease course aspects of community-acquired
pneumonia in chronic heart failure has enabled the development of practical
recommendations for diagnostic management, both at the prehospital and hospital
stages of care.
Implementation of the scientific results: The practical recommendations are
used in the General Therapy Department and the Pneumology Division of Municipal
Clinical Hospital "Holy Trinity" and in the didactic process within the Discipline of
Clinical Syntheses, Department of Internal Medicine of "Nicolae Testemițanu" State
University of Medicine and Pharmacy.
